メトホルミンはPRKAとSIRT1を活性化する
metformin alleviates hepatic steatosis through PRKA-independent, SIRT1-mediated effects on the autophagy machinery.
The traditional pathways of autophagy induction are either through PRKA (protein kinase, AMP-activated)-MTOR-ULK1 mediated signaling, activated by an increase in the AMP/ATP ratio, or the sirtuin class of histone/protein deacetylases (SIRT1)-FOXO pathway, activated by increased NAD+.3,4 In addition, metformin is well-established to activate both PRKA and the NAD+-dependent deacetylase SIRT1.5
2024年6月15日 | カテゴリー：糖尿病 |
