メトフォルミンが肥満に効く文献はものすごく多い
Metformin: Mechanisms in Human Obesity and Weight Loss.
Curr Obes Rep. 2019 Jun;8(2):156-164. doi: 10.1007/s13679-019-00335-3.PMID: 30874963 Free PMC article. Review.
The purpose of this manuscript is to review the mechanisms that underlie metformin's effects on obesity. RECENT FINDINGS: Metformin is a first-line therapy for type 2 diabetes. ...Metformin is also being explored in the management of obesity
Effectiveness of metformin on weight loss in non-diabetic individuals with obesity.
Exp Clin Endocrinol Diabetes. 2013 Jan;121(1):27-31. doi: 10.1055/s-0032-1327734. Epub 2012 Nov 12.PMID: 23147210
OBJECTIVE: The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials with inconclusive results. ...The percentage of weight loss was independent of age, sex or BMI. CONCLUSION: Metformin is an effective drug to reduce we …
Obesity and Diabetes.
Nurs Clin North Am. 2021 Dec;56(4):527-541. doi: 10.1016/j.cnur.2021.07.008.PMID: 34749892 Review.
Obesity is the most significant risk factor for the development of diabetes. Both obesity and diabetes rates have continued to increase in tandem and pose increased mortality for patients and increased health care costs for the community. ...
Anti-Obesity Effects of Metformin: A Scoping Review Evaluating the Feasibility of Brown Adipose Tissue as a Therapeutic Target.
Int J Mol Sci. 2023 Jan 23;24(3):2227. doi: 10.3390/ijms24032227.PMID: 36768561 Free PMC article. Review.
The summarized evidence suggests that metformin can reduce body weight, enhance insulin sensitivity, and improve glucose metabolism by promoting BAT thermogenic activity in preclinical models of obesity. ...This review explored critical components including effectiv …
Obesity and metformin.
J Pediatr Endocrinol Metab. 2012;25(1-2):1. doi: 10.1515/jpem-2012-0999.PMID: 22570944 No abstract available.
Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport.
Int J Mol Sci. 2022 Jan 23;23(3):1264. doi: 10.3390/ijms23031264.PMID: 35163187 Free PMC article. Review.
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. ...However, the mechanisms behind this effect and the critical metformin …
Metformin Treatment of Pediatric Obesity.
Pediatrics. 2021 Mar;147(3):e2020044982. doi: 10.1542/peds.2020-044982.PMID: 33608414 No abstract available.
Metformin in obesity, cancer and aging: addressing controversies.
Aging (Albany NY). 2012 May;4(5):320-9. doi: 10.18632/aging.100455.PMID: 22589237 Free PMC article. Review.
Metformin, an oral anti-diabetic drug, is being considered increasingly for treatment and prevention of cancer, obesity as well as for the extension of healthy lifespan. ...Studies of the potential antiaging effects of antidiabetic biguanides, such as metformin …
Pharmacological Strategies for Insulin Sensitivity in Obesity and Cancer: Thiazolidinediones and Metformin.
Curr Pharm Des. 2020;26(9):932-945. doi: 10.2174/1381612826666200122124116.PMID: 31969093 Review.
In this regard, thiazolidinediones (TZD) possess multiple molecular targets and regulate PPARgamma in obesity and cancer related to insulin resistance, while metformin acts through the AMPK pathway. OBJECTIVE: The aim of this study was to review TZD and metformin …
Metformin for obesity in children and adolescents: a systematic review.
Diabetes Care. 2009 Sep;32(9):1743-5. doi: 10.2337/dc09-0258. Epub 2009 Jun 5.PMID: 19502540 Free PMC article. Review.
OBJECTIVE: To summarize the efficacy of metformin in reducing BMI and cardiometabolic risk in obese children and adolescents without diabetes. ...CONCLUSIONS: Metformin appears to be moderately efficacious in reducing BMI and insulin resistance in hyperinsuli
