challenging to fork the king and the rook in cancer therapy
second family of proteasome inhibitir
fnding the molecules to bind proteasome beta subunit and proteins to be ubiquitinated in cancer cells
cyc;in B,
HIF,
NFkB
Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co-opt this homeostatic system to drive cancer progression. HIFs activate the transcription of thousands of genes that mediate angiogenesis, cancer stem cell specification, cell motility, epithelial-mesenchymal transition, extracellular matrix remodeling, glucose and lipid metabolism, immune evasion, invasion, and metastasis. In this Review, the mechanisms and consequences of HIF activation in cancer cells are presented. The current status and future prospects of small-molecule HIF inhibitors for use as cancer therapeutics are discussed.
2024年9月23日 | カテゴリー：AUTODOCK VINA , 各種治療学, 癌の病態生理と治療学 |
